Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons
نویسندگان
چکیده
منابع مشابه
BPAG1n4 is essential for retrograde axonal transport in sensory neurons
Disruption of the BPAG1 (bullous pemphigoid antigen 1) gene results in progressive deterioration in motor function and devastating sensory neurodegeneration in the null mice. We have previously demonstrated that BPAG1n1 and BPAG1n3 play important roles in organizing cytoskeletal networks in vivo. Here, we characterize functions of a novel BPAG1 neuronal isoform, BPAG1n4. Results obtained from y...
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Following injury to their peripheral branches, mechanosensory neurons in Aplysia display long-term plasticity that is expressed as soma hyperexcitability, synaptic facilitation, and neurite outgrowth. To investigate the nature of signals that convey information about distant axonal injury, we have investigated the development of injury-induced soma hyperexcitability in two in vitro preparations...
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Poliovirus (PV), when injected intramuscularly into the calf, is incorporated into the sciatic nerve and causes an initial paralysis of the inoculated limb in transgenic mice carrying the human PV receptor (hPVR/CD155) gene. Here, we demonstrated by using an immunoelectron microscope that PV particles exist on vesicle structures in nerve terminals of neuromuscular junctions. We also demonstrate...
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We used 3H N-succinimidyl propionate to covalently label in vivo proteins of the rat sciatic nerve, and studied the accumulation of radioactively labeled proteins in the cell bodies of the ipsilateral dorsal root ganglion and ventral horn of spinal cord to assess retrograde axonal transport in sensory and motor neurons respectively. In each case the early accumulation of a small amount of radio...
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Different views of the location and organization of corticospinal (CS) neurons in the rat have resulted from fiber degeneration studies, electrophysiologically derived somatotopic maps, studies of CS axonal branching, and functional alterations af’ter ablation of parts of the motor-sensory cortex. To locate more precisely CS neurons that projected to different levels of the spinal cord, and to ...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2011
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2011.197